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Invitrogen
DLL4 (delta-like 4) Monoclonal Antibody (MHD4-46)
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DLL4 (delta-like 4) Antibody (MA5-28625) in Flow
Separation of DLL4 transfected HD4 cells stained using anti-DLL4 (MHD4-46) purified Monoclonal antibody (Product # MA5-28625) (low endotoxin, concentration in sample 3 µg/mL, GAM APC, red-filled) from DLL4 transfected HD4 cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-28625
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
MHD4-46
抗原
recombinant soluble human DLL4
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.
Functional Application: Blocking.
靶标信息
Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 protein; Delta-like protein 4; Delta4; Drosophila Delta homolog 4; MGC126344; notch ligand delta-2; notch ligand DLL4; unnamed protein product
基因别名: AOS6; delta4; DLL4; hdelta2; UNQ1895/PRO4341
UniProt ID: (Human) Q9NR61
Entrez Gene ID: (Human) 54567
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
patterning of blood vessels
blood vessel remodeling
aortic valve morphogenesis
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
ventricular trabecula myocardium morphogenesis
pericardium morphogenesis
cell communication
signal transduction
Notch signaling pathway
nervous system development
visual perception
negative regulation of cell proliferation
negative regulation of endothelial cell migration
positive regulation of gene expression
negative regulation of gene expression
cell differentiation
T cell differentiation
dorsal aorta morphogenesis
cellular response to vascular endothelial growth factor stimulus
negative regulation of blood vessel endothelial cell migration
cellular response to fibroblast growth factor stimulus
negative regulation of Notch signaling pathway
positive regulation of Notch signaling pathway
animal organ development
system development
regulation of neurogenesis
ventral spinal cord interneuron fate commitment
regulation of neural retina development
blood vessel lumenization
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
positive regulation of neural precursor cell proliferation
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