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Invitrogen
CD147 Recombinant Rabbit Monoclonal Antibody (125)
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Product Details
MA5-29060
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
125
Immunogen
Recombinant Human CD147 protein (Met1-His205)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.0, with 10% trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human CD147/Basigin/BSG.
Target Information
CD147 (basigin, neurothelin, OX-47, 5A11, CE9, M6, EMMPRIN, extracellular matrix metalloproteinase inducer, TCSF, tumour cell-derived collagenase-stimulatory factor) is a 50-60 kDa glycoprotein with multiple glycosylated forms. CD147 is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. CD147 is also a member of the immunoglobulin superfamily. The highest level of CD147 expression is on metabolically active cells, such as lymphoblasts, inflammatory cells, brown adipocytes and malignant tumor cells. CD147 has multiple functions, including facilitating of cell surface expression of monocarboxylate transporter proteins and extracellular matrix metalloproteinases, regulation of integrin functions, it plays roles in cell development and activation, fetal development or retinal function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 5F7; adhesion molecule; amino acid feature: intracellular domain, aa 707 .. 829; amino acid feature: transmembrane domain, aa 638 .. 706; amino acid feature: extracellular domain, aa 86 .. 637; Basigin; CD147; Collagenase stimulatory factor; EMMPRIN; Extracellular matrix metalloproteinase inducer; HAb18G; Hepatoma-associated antigen; Leukocyte activation antigen M6; OK blood group antigen; retinal glycoprotein; TCSF; Tumor cell-derived collagenase stimulatory factor; unnamed protein product
Gene Aliases: 5F7; BSG; CD147; EMMPRIN; EMPRIN; HAb18G; OK; TCSF; UNQ6505/PRO21383
UniProt ID: (Human) P35613
Entrez Gene ID: (Human) 682
angiogenesis
neural retina development
homophilic cell adhesion via plasma membrane adhesion molecules
cell surface receptor signaling pathway
axon guidance
embryo implantation
positive regulation of vascular endothelial growth factor production
positive regulation of endothelial cell migration
neutrophil chemotaxis
positive regulation of interleukin-6 production
odontogenesis of dentin-containing tooth
response to peptide hormone
photoreceptor cell maintenance
positive regulation of viral entry into host cell
response to mercury ion
decidualization
viral entry into host cell
response to cAMP
endothelial tube morphogenesis
dendrite self-avoidance
protein localization to plasma membrane
positive regulation of matrix metallopeptidase secretion
neuron projection extension
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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