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Phospho-Ask1 (Ser83) Recombinant Rabbit Monoclonal Antibody (Ask1S83-G4), APC

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Phospho-Ask1 (Ser83) Recombinant Rabbit Monoclonal Antibody (Ask1S83-G4), APC

Product Details

MA5-36976

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

5 µL/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

Ask1S83-G4

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Ser83 of human phospho Ask1.
View immunogen

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Purification

Protein A/G

Storage buffer

PBS with 0.20% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2896911

Target Information

MAP3K5 (ASK1) is a serine/threonine kinase that is abundantly expressed in human heart and pancreas and are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activates c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: apoptosis signal regulating kinase 1; Apoptosis signal-regulating kinase 1; ASK 1; ASK-1; EC 2.7.11.25; kinase ASK1; M3K5; MAP/ERK kinase kinase 5; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5; mitogen activated protein kinase kinase kinase 5; Mitogen-activated protein kinase kinase kinase 5; RP3-325F22.4; unnamed protein product

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Gene Aliases: 7420452D20Rik; ASK; ASK1; MAP3K5; MAPKKK5; MEKK5; RGD1306565

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UniProt ID: (Human) Q99683, (Mouse) O35099

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Entrez Gene ID: (Human) 4217, (Mouse) 26408, (Rat) 365057

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Function(s)
nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity JUN kinase kinase kinase activity MAP kinase kinase kinase activity protein binding ATP binding kinase activity transferase activity protein kinase binding protein phosphatase binding protein domain specific binding identical protein binding protein homodimerization activity metal ion binding protein serine kinase activity cysteine-type endopeptidase activator activity involved in apoptotic process transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
MAPK cascade immune system process response to ischemia apoptotic process JNK cascade intrinsic apoptotic signaling pathway in response to oxidative stress positive regulation of cardiac muscle cell apoptotic process cellular response to amino acid starvation response to endoplasmic reticulum stress neuron intrinsic apoptotic signaling pathway in response to oxidative stress p38MAPK cascade positive regulation of apoptotic process regulation of programmed cell death positive regulation of MAPK cascade innate immune response positive regulation of myoblast differentiation positive regulation of transcription, DNA-templated positive regulation of JNK cascade neuron apoptotic process stress-activated MAPK cascade intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to hydrogen peroxide cellular response to tumor necrosis factor endothelial cell apoptotic process cellular senescence apoptotic signaling pathway programmed necrotic cell death positive regulation of p38MAPK cascade cellular response to reactive nitrogen species positive regulation of vascular smooth muscle cell proliferation activation of MAPKK activity activation of MAPK activity positive regulation of protein phosphorylation protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cell death phosphorylation positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of JUN kinase activity positive regulation of neuron death
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