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Invitrogen
Phospho-CD247 (CD3 zeta) (Lys72) Monoclonal Antibody (EM-26), Alexa Fluor™ 647
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Phospho-CD247 (CD3 zeta) (Lys72) Antibody (MA5-38685) in Flow
Flow cytometry of CD247 (CD3 zeta) in CD3 positive T cells (and mouse IgG1 control). Samples were incubated with CD247 (CD3 zeta) monoclonal antibody (Product # MA5-38685) followed by Alexa Fluor 647 at a dilution of 3 µg/mL (red-filled and black-dashed).
产品信息
MA5-38685
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
EM-26
抗原
A phospho specific peptide corresponding to the amino acids surrounding tyrosine 72 of mouse CD3 zeta linked to KLH
偶联物
激发/发射光谱
650/671 nm
查看光谱
形式
Liquid
浓度
100 µg/mL
纯化类型
Size-exclusion chromatography
保存液
PBS with 0.2% BSA
内含物
15mM sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes phosphorylated intracellular tyrosine 72 of CD3 zeta chain (CD247), which is a component of TCR/CD3 complex expressed on T cells.
靶标信息
CD3z complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules, and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Diseases associated with CD3z include Immunodeficiency 25 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD247; CD247 antigen; CD247 antigen, zeta subunit; CD3 antigen, zeta polypeptide; CD3-epsilon; CD3-zeta/eta; CD3e antigen; CD3Z antigen, zeta polypeptide (TiT3 complex); CD3zeta chain; FLJ18683; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor T3 eta chain; T-cell receptor T3 zeta chain; T-cell surface glycoprotein CD3 zeta chain; T3E; TCR zeta chain; TCRE
基因别名: 4930549J05Rik; A430104F18Rik; AW552088; CD247; Cd3; Cd3-eta; CD3-ZETA; CD3H; CD3Q; CD3Z; Cd3zeta; IMD25; T3Z; Tcrk; TCRZ
UniProt ID: (Human) P20963, (Mouse) P24161
Entrez Gene ID: (Human) 919, (Mouse) 12503
