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Invitrogen
MHC Class I Monoclonal Antibody (IVA26), Alexa Fluor™ 488
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MHC Class I Antibody (MA5-44137) in Flow
Separation of bovine lymphocytes stained using anti-bovine MHC Class I (IVA26) Alexa Fluor® 488 Monoclonal antibody (Product # MA5-44137), concentration in sample 1 µg/mL (red-filled) from bovine lymphocytes stained using mouse IgG1 isotype control (MOPC-21) Alexa Fluor® 488 antibody (concentration in sample 1 µg/mL, black-dashed) in flow cytometry analysis (surface staining) of bovine peripheral whole blood.
产品信息
MA5-44137
应用
建议稀释比
已发表文章
产品规格
种属反应
Avian,
Bovine,
Human,
Mouse,
Sheep,
Pig,
Rabbit
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
IVA26
抗原
bovine lymphocytes
偶联物
激发/发射光谱
499/520 nm
查看光谱
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Size-exclusion chromatography
保存液
PBS
内含物
15mM sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes an extracellular epitope on MHC class I (alpha + beta2m chains) expressed in various animals.
靶标信息
Like their mammalian counterparts, avian MHC Class I molecules, also known as B-F antigens, consist of a highly polymorphic alpha-chain noncovalently bound to the invariant beta2-microglobulin subunit. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. The monoclonal antibody F21-2 also reacts with turkey MHC Class I.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
生物信息学
蛋白别名: cell surface glycoprotein; integral membrane protein; heavy chain; HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; HLA protein allele A25; HLA-A; HLA-A 2402; HLA-A*0201 alpha chain; human leukocyte antigen; HLA-A*0204; HLA-A*0207 alpha chain; human leukocyte antigen; HLA-A-0102 allele; HLA-A24AK; HLA-A25; human leukocyte antigen; Human leukocyte antigen A; leukocyte antigen class I-A; major histocompatibility complex class I A; MHC class I antigen; MHC class I antigen HLA-A heavy chain; MHC HLA-A cell surface antigen; MHC HLA-A10-alpha-2 chain precursor; MHC HLA-A2.4a chain; MHC HLA-A24 cell surface glycoprotein; ovar-MHCI-B564; ovar-MHCI-D5; ovar-MHCI-F12; unnamed protein product
基因别名: HLA-A; HLAA; Ovar-I
UniProt ID: (Human) P04439
Entrez Gene ID: (Human) 3105, (Sheep) 101108963, (Sheep) 100171394
T cell mediated cytotoxicity
positive regulation of T cell mediated cytotoxicity
adaptive immune response
immune system process
T cell mediated cytotoxicity directed against tumor cell target
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
peptide antigen assembly with MHC class I protein complex
positive regulation of T cell cytokine production
immune response
detection of bacterium
antibacterial humoral response
antigen processing and presentation
antigen processing and presentation of endogenous peptide antigen via MHC class I
positive regulation of interferon-gamma production
CD8-positive, alpha-beta T cell activation
protection from natural killer cell mediated cytotoxicity
antigen processing and presentation of exogenous peptide antigen via MHC class I
innate immune response
defense response to Gram-positive bacterium
T cell receptor signaling pathway
positive regulation of CD8-positive, alpha-beta T cell proliferation
positive regulation of memory T cell activation
positive regulation of CD8-positive, alpha-beta T cell activation
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