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Invitrogen
Rhodopsin Monoclonal Antibody (4D2), FITC
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Rhodopsin Antibody (MA5-45245) in IHC
Immunohistochemistry analysis using retina. Samples were incubated with Rhodopsin monoclonal antibody (Product # MA5-45245) at 1:1,000, followed by FITC Goat Anti-Mouse (green). Counterstain used was DAPI (blue) nuclear stain. Localization: Staining of photoreceptor outer segment (OS). Other layers of the retina: IS – inner segment; ONL – outer nuclear layer; OPL – outer plexiform layer; INL – inner nuclear layer; IPL – inner plexiform layer; GCL – ganglion cell layer.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-45245
产品规格
种属反应
Amphibian,
Avian,
Bovine,
Fish,
Human,
Mouse,
Shark
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
4D2
抗原
Bovine Rhodopsin
偶联物
FITC
FITC
FITC
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
9.09mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine
内含物
no preservative
保存条件
4°C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
1 µg/mL of MA5-45245 was sufficient for detection of rhodopsin in 10 µg of rat eye lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 40kDa. Binds specifically to the N-terminus of Rhodopsin. Does not detect Rhodopsin in invertebrates.
靶标信息
Visual pigments such as rhodopsin and porphyropsin are light-absorbing molecules that mediate vision. Rhodopsin consists of an apoprotein, opsin, covalently linked to 11-cis-retinal. This receptor is coupled to the activation of phospholipase C. Porphyropsin consists of opsin covalently linked to 11-cis 3,4-didehydroretinal.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: L opsin; long wavelength sensitive opsin; LWS opsin; MGC138309; MGC138311; OPN 2; opsin 2; opsin 2, rod pigment; opsin-2; red opsin; rhodopsin; rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant); rod opsin; RP 4; unnamed protein product
基因别名: CSNBAD1; Noerg1; OPN2; Ops; RP4
UniProt ID: (Bovine) P02699, (Human) P08100, (Mouse) P15409
Entrez Gene ID: (Bovine) 509933, (Human) 6010, (Mouse) 212541
G-protein alpha-subunit binding
opsin binding
guanyl-nucleotide exchange factor activity
11-cis retinal binding
protein binding
G-protein coupled photoreceptor activity
zinc ion binding
identical protein binding
arrestin family protein binding
G-protein coupled receptor activity
retinal binding
spectrin binding
G-protein coupled receptor
protein phosphorylation
visual perception
phototransduction, visible light
response to light stimulus
absorption of visible light
rhodopsin mediated signaling pathway
protein-chromophore linkage
photoreceptor cell maintenance
retina development in camera-type eye
G-protein coupled receptor signaling pathway
phototransduction
cellular response to light stimulus
transducin-mediated opsin signaling pathway
microtubule cytoskeleton organization
detection of light stimulus
red, far-red light phototransduction
response to light intensity
gene expression
deactivation of rhodopsin mediated signaling
thermotaxis
sensory perception of light stimulus
detection of temperature stimulus involved in thermoception
podosome assembly
rod bipolar cell differentiation
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