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Invitrogen

LRRK2 Monoclonal Antibody (N231B/34), FITC

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LRRK2 Monoclonal Antibody (N231B/34), FITC

Product Details

MA5-45642

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100
-

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

N231B/34

Immunogen

Fusion protein amino acids 841-960 of human LRRK2.
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

9.09mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine

Contains

no preservative

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932096

Product Specific Information

81% identical in mouse, 80% identical in rat. <30% identity with LRRK1.

10 µg/mL of MA5-45642 was sufficient for detection of LRRK2/Dardarin in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects >200kDa.

This antibody was formerly sold as clone S231B-34.

Target Information

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson's disease. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BC 300-268; Dardarin; DKFZp434H2111; FLJ45829; Leucine-rich repeat serine/threonine-protein kinase 2; LRR kinase 2; LRRK 2; LRRK-2

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Gene Aliases: LRRK2; PARK8

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Entrez Gene ID: (Rat) 300160

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Function(s)
SNARE binding glycoprotein binding molecular_function actin binding GTPase activity protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity GTPase activator activity ATP binding GTP binding tubulin binding kinase activity Rho GTPase binding syntaxin-1 binding clathrin binding GTP-dependent protein kinase activity peroxidase inhibitor activity identical protein binding protein homodimerization activity ion channel binding protein kinase A binding scaffold/adaptor protein
Process(es)
MAPK cascade activation of MAPKK activity activation of MAPK activity negative regulation of protein phosphorylation positive regulation of protein phosphorylation protein phosphorylation endocytosis response to oxidative stress small GTPase mediated signal transduction neuromuscular junction development determination of adult lifespan positive regulation of autophagy regulation of protein kinase A signaling negative regulation of protein processing regulation of neuron maturation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation olfactory bulb development tangential migration from the subventricular zone to the olfactory bulb positive regulation of protein ubiquitination negative regulation of protein binding positive regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of GTPase activity cellular response to oxidative stress cellular protein localization intracellular signal transduction regulation of kidney size exploration behavior locomotory exploration behavior regulation of locomotion regulation of membrane potential positive regulation of programmed cell death positive regulation of GTPase activity protein autophosphorylation intracellular distribution of mitochondria neuron projection morphogenesis regulation of mitochondrial depolarization regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential regulation of dopamine receptor signaling pathway positive regulation of dopamine receptor signaling pathway regulation of dendritic spine morphogenesis neuron death cellular response to manganese ion cellular response to organic cyclic compound reactive oxygen species metabolic process regulation of neuron death negative regulation of neuron death negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of protein autoubiquitination regulation of neuroblast proliferation negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation negative regulation of hydrogen peroxide-induced cell death negative regulation of protein targeting to mitochondrion cellular response to dopamine regulation of branching morphogenesis of a nerve regulation of synaptic vesicle exocytosis negative regulation of peroxidase activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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