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Invitrogen
ITGA4 Monoclonal Antibody (9F10), Functional Grade
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ITGA4 Antibody (MA562325) in Flow
Flow cytometry (surface staining) of ITGA4 in human peripheral whole blood. Samples were stained with ITGA4 monoclonal antibody (Product # MA562325) using a dilution of 1 µg/mL. Separation of human CD49d positive lymphocytes (red-filled) from neutrophil granulocytes (black-dashed).
产品信息
MA562325
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Dog,
Horse,
Cat,
Human,
Non-human primate,
Sheep
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
9F10
抗原
Proprietary Immunogen.
偶联物
Functional Grade
Functional Grade
Functional Grade
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49d; Integrin alpha-4; Integrin alpha-4-like protein; Integrin alpha-IV; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); ITGA-IV; unnamed protein product; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 subunit alpha
基因别名: CD49D; IA4; ITGA4
UniProt ID: (Human) P13612
Entrez Gene ID: (Human) 3676, (Sheep) 443499, (Horse) 100067886, (Dog) 488429, (Bovine) 282882
immune response in gut-associated lymphoid tissue
positive regulation of leukocyte migration
cell-matrix adhesion involved in ameboidal cell migration
cell adhesion
leukocyte cell-cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
tissue development
B cell differentiation
cell-cell adhesion mediated by integrin
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
endodermal cell differentiation
receptor clustering
negative regulation of vasoconstriction
embryonic morphogenesis
leukocyte migration
leukocyte tethering or rolling
diapedesis
axonogenesis involved in innervation
cellular response to cytokine stimulus
negative regulation of protein homodimerization activity
cell-cell adhesion
import into cell
positive regulation of leukocyte cell-cell adhesion
positive regulation of leukocyte tethering or rolling
cellular response to beta-amyloid
positive regulation of vascular endothelial cell proliferation
neuron projection extension
clathrin-mediated extracellular exosome endocytosis
positive regulation of endothelial cell apoptotic process
positive regulation of T cell migration
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