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Invitrogen
CD49a Monoclonal Antibody (TS2/7), APC
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FIGURE: 1 / 1
CD49a Antibody (MA562398) in Flow
Flow cytometry (surface staining) of CD49a in HeLa cells. Samples were stained with CD49a monoclonal antibody (Product # MA562398) using a dilution of 0.56 µg/mL. Separation of stained HeLa cells (red-filled) from HeLa cells stained using mouse IgG1 isotype control (MOPC-21) APC antibody (0.56 µg/mL, black-dashed).
Product Details
MA562398
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
TS2/7
Immunogen
Human CTL line.
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Concentration
0.04 mg/mL
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD49 antigen-like family member A; CD49a; Integrin alpha-1; Laminin and collagen receptor; unnamed protein product; very late activation protein 1; very late antigen-1; VLA-1
Gene Aliases: CD49a; ITGA1; VLA1
UniProt ID: (Human) P56199
Entrez Gene ID: (Human) 3672
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
negative regulation of cell proliferation
neutrophil chemotaxis
negative regulation of epidermal growth factor receptor signaling pathway
vasodilation
positive regulation of MAPK cascade
positive regulation of neuron apoptotic process
cellular extravasation
neuron projection morphogenesis
cell chemotaxis
cell-cell adhesion
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