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ILT7 is a pDC-specific IgG-like transcript and is a member of the leukocyte immunoglobulin-like receptor gene family. This receptor, in complex with FcER1a, transduces ITAM-mediated signals which negatively modulate type I IFN production by pDC. ILT7 is thus a potential target to regulate Type 1 IFN production by pDC, which play a major role during viral infection, auto-immune diseases and anti-cancer immunity. Additionally, ILT7, along with CD123 and BDCA-2, can be used to identify or classify subsets of pDCalong with TLR expression and TLR mediated immune responses.
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Protein Aliases: CD85 antigen-like family member G; CD85g; ILT-7; Immunoglobulin-like transcript 7; Leukocyte immunoglobulin-like receptor subfamily A member 4
Gene Aliases: ILT7; LILRA4
Entrez Gene ID: (Human) 23547
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