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Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. Cutokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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蛋白别名: CK-8; cytokeratin 8; Cytokeratin-8; Cytokeratin-A; K8; KERA; Keratin, type II cytoskeletal 8; Keratin-8; type II cytokeratin A (no.8); Type-II keratin Kb8
基因别名: CYK8; KRT2-8; KRT8
UniProt ID: (Bovine) P05786
Entrez Gene ID: (Rabbit) 100348891, (Bovine) 281269, (Pig) 100152077, (Sheep) 101110495