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Immunogen sequence: SFLKGLSDKQ REEHYFCKDF VRLKKIPTWK EMAKGVAVKV EEPRYKKDKQ LNEKISLLRS DITKLEV
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 85%.
Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: [Protein ADP-ribosylaspartate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase; [Protein ADP-ribosylglutamate] hydrolase MACROD1; ADP-ribose glycohydrolase MACROD1; MACRO domain-containing protein 1; O-acetyl-ADP-ribose deacetylase MACROD1; Protein LRP16
基因别名: LRP16; MACROD1
UniProt ID: (Human) Q9BQ69
Entrez Gene ID: (Human) 28992