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Invitrogen
MAFA Polyclonal Antibody
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产品信息
PA5-113855
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N terminal region of human MAFA (aa 110-159).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: KPALEDLYWM SGYQHHLNPE ALNLTPEDAV EALIGSGHHG AHHGAHHPAA
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 100%; Dog: 79%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 83%
靶标信息
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene. MAFA cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its ocogenic activity. Serves as an ocogene or tumor supressor depending on the cell context.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Mafa homolog; Pancreatic beta-cell-specific transcriptional activator; RIPE3b1 factor; Transcription factor MafA; transcription factor RIPE3b1; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
基因别名: hMafA; MAFA; RIPE3b1
UniProt ID: (Human) Q8NHW3, (Mouse) Q8CF90
Entrez Gene ID: (Human) 389692, (Mouse) 378435
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein homodimerization activity
protein heterodimerization activity
sequence-specific DNA binding
basic leucine zipper transcription factor
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
nitric oxide mediated signal transduction
response to glucose
insulin secretion
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
positive regulation of transcription, DNA-templated
