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Invitrogen
MAP4K3 Monoclonal Antibody (219CT8.3.1)
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MAP4K3 Antibody (MA5-37511) in IHC (P)
Immunohistochemistry (Paraffin) analysis of MAP4K3 in paraffin-embedded human skeletal muscle sections using the MAP4K3 Monoclonal Antibody (Product # MA5-37511) at a dilution of 1:100. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
产品信息
MA5-37511
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgM, kappa
分类
Monoclonal
类型
Antibody
克隆号
219CT8.3.1
抗原
MAP4K3 recombinant protein
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Euglobulin precipitation
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
MAP4K3 (also known as GLK) is a member of the STE20 family of serine/threonine protein kinases and contains N-terminal catalytic domain and C-terminal regulatory domain. MAP4K3 is upstream of the MEKK1 target and is stimulated by UV radiation and TNF-alpha and can lead to the activation of the JNK signaling pathway. MAP4K3 can directly activate PKC-T, during TCR signaling and people with systemic lupus erythematosus show considerable enhanced MAP4K3 expression and activation of PKC-T, and the kinase IKK in T cells. MAP4K3 can act as a pro-apoptotic kinase which orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase 1 (MEKK1). MAP4K3 previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase 3 (MAP4K3).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: germinal center kinase-like kinase; Germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; Mitogen-activated protein kinase kinase kinase kinase 3
基因别名: GLK; MAP4K3; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1
UniProt ID: (Human) Q8IVH8
Entrez Gene ID: (Human) 8491
