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Invitrogen
MARK1 Polyclonal Antibody
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产品信息
PA5-32914
产品规格
种属反应
Bat,
Bovine,
Dog,
Human,
Non-human primate,
Rabbit
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 18 amino acid peptide from N-terminus of human MARK1.
偶联物
形式
Liquid
浓度
0.75 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Dog, Bat, Bovine, Panda, Rabbit, Opossum (100%); Elephant, Horse, Lizard (94%); Rat, Turkey, Chicken, Platypus (89%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
靶标信息
MARK1 (MARK) is a serine/threonine kinase which is involved in cytoskeletal organization and biogenesis. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1 is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MAP/microtubule affinity-regulating kinase 1; MARK1; Par-1c; PAR1 homolog c; Serine/threonine-protein kinase MARK1
基因别名: KIAA1477; MARK; MARK1; Par-1c; Par1c
UniProt ID: (Human) Q9P0L2
Entrez Gene ID: (Human) 4139, (Dog) 478965, (Bovine) 539563, (Rabbit) 100339168
