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Invitrogen
MASP-3 (Zaltenibart Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA562671
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG4, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA562671 is a chimeric antibody. The variable regions from one species have been grafted to the backbone of the other species.
靶标信息
The MASP-3 gene encodes the Mannan-Binding Lectin Serine Protease 3, a crucial component of the lectin pathway of the complement system, which is part of the innate immune response. The MASP-3 protein is synthesized as a zymogen and requires proteolytic activation to become functionally active. Structurally, MASP-3 comprises several domains, including a C1r/C1s, Uegf, Bmp1 (CUB) domain, an epidermal growth factor (EGF)-like domain, and a serine protease domain. Functionally, MASP-3 regulates the activation of the alternative complement pathway by cleaving components such as factor D, ultimately contributing to the formation of the C3 convertase and subsequent immune response. Genetic variations in the MASP-3 gene have been implicated in immune system disorders and susceptibility to infections.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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