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It is not recommended to aliquot this antibody.
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. MAVS is a mitochondrial membrane protein that was identified as a critical component in the IFN beta signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. MAVS is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. MAVS also interacts with the IKK-alpha, IKK-beta and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. Multiple isoforms of MAVS are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CARD adapter inducing interferon beta; Cardif; IFN-beta promoter stimulator-1; Interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; IPS-1; MAVS; mitochondrial anti-viral signaling protein; Mitochondrial antiviral-signaling protein; virus-induced signaling adapter; virus-induced signaling adaptor; Virus-induced-signaling adapter; VISA
基因别名: cardif; D430028G21Rik; IPS-1; Ips1; Mavs; Visa
UniProt ID: (Mouse) Q8VCF0, (Rat) Q66HG9
Entrez Gene ID: (Mouse) 228607, (Rat) 311430