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Abnova
MBD1 Monoclonal Antibody (2B10)
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产品信息
H00004152-M05J
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
2B10
抗原
MBD1 (NP_056671, 415 a.a. approximately 508 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: HHLGPTLKPT LATRTAQPDH TQAPTKQEAG GGFVLPPPGT DLVFLREGAS SPVQVPGPVA ASTEALLQEA QCSGLSWVVA LPQVKQEKAD TQDE
Cell culture grade monoclonal antibodies are obtained by purifying "hybridoma culture medium" which completely eliminates any contamination of mice. They have high affinity, high purity, and no contamination.
靶标信息
Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CXXC-type zinc finger protein 3; methyl-CpG binding domain protein 1 isoform PCM1; Methyl-CpG-binding domain protein 1; Methyl-CpG-binding protein MBD1; Protein containing methyl-CpG-binding domain 1; the regulator of fibroblast growth factor 2 (FGF-2) transcription
基因别名: CXXC3; MBD1; PCM1; RFT
UniProt ID: (Human) Q9UIS9
Entrez Gene ID: (Human) 4152
negative regulation of transcription from RNA polymerase II promoter
methylation-dependent chromatin silencing
transcription from RNA polymerase II promoter
heart development
aging
response to fluoxetine
neuron differentiation
response to nutrient levels
response to estradiol
response to cocaine
regulation of DNA methylation
negative regulation of transcription, DNA-templated
negative regulation of astrocyte differentiation
