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Invitrogen
MBL2 Monoclonal Antibody (3E7)
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MBL2 Antibody (MA1-40145) in Flow
Science advances 2023 -
Fig. 2. MBL and hItln1 binding to microbial populations in human stool samples. ( A ) Schematic of flow cytometry-based assay to measure soluble lectin binding to stool microbiome. ( B ) Flow cytometry analysis of healthy human stool plotted as SYTO BC against lectin binding (anti-Strep DY649). Panels show no lectin control (column 1), and strep-MBL (top row), or strep-hItln1 (bottom row) binding in the pre... View More
产品信息
MA1-40145
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
C. elegans,
Human,
Rhesus monkey,
Yeast
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
3E7
抗原
Serum isolated human RaRF
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Protein G
保存液
PBS with 0.1% BSA
内含物
no preservative
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-40145 detects MBL from human samples.
The MA1-40145 immunogen is Mannose Binding Lectin (MBL).
MA1-40145 has been successfully used in flow cytometry, Western blot, ELISA, Functional Assays, and immunohistochemistry (frozen) applications.
Negative control: Nonimmune normal serum or TBS.
Endotoxin <24 EU/mg.
靶标信息
MBL2 is a calcium-dependent lectin involved in innate immune defense. It binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. It also binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. MBL2 may bind DNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Collectin-1; Collectin1; mannan-binding lectin; Mannan-binding protein; Mannose-binding lectin; mannose-binding lectin (protein C) 2, soluble (opsonic defect); mannose-binding lectin 2, soluble (opsonic defect); Mannose-binding protein C; MBP-C; MBP1; MBPC; MGC116832; MGC116833
基因别名: COLEC1; HSMBPC; MBL; MBL2; MBL2D; MBP; MBP-C; MBP1; MBPD
UniProt ID: (Human) P11226
Entrez Gene ID: (Human) 4153
complement activation, lectin pathway
proteolysis
acute-phase response
complement activation
complement activation, classical pathway
response to oxidative stress
opsonization
defense response to bacterium
negative regulation of growth of symbiont in host
innate immune response
negative regulation of viral process
positive regulation of phagocytosis
defense response to Gram-positive bacterium
killing by host of symbiont cells
