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Invitrogen
MC1R Polyclonal Antibody
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MC1R Antibody (PA5-75342) in WB
Western blot analysis of MC1R in various lysates. Samples were incubated with MC1R polyclonal antibody (Product # PA5-75342) using a dilution of 1:1,000. Lane 1: Hela whole cell lysate (40 µg); Lane 2: The Brain tissue lysate of Rat (40 µg); Lane 3: The Brain tissue lysate of Mouse (40 µg).
产品信息
PA5-75342
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 271-317 of Human MC1-R.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: alpha melanocyte stimulating hormone receptor; extension recessive yellow; MC1 receptor; MC1-R; melanocortin 1 receptor; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); Melanocortin receptor 1; melanocortin-1 receptor; Melanocyte-stimulating hormone receptor; melanotropin receptor; MSH-R; tobacco darkening
基因别名: CMM5; e; MC1R; MSH-R; MSHR; Mshra; SHEP2; Tob
UniProt ID: (Human) Q01726, (Mouse) Q01727
Entrez Gene ID: (Human) 4157, (Rat) 102552838, (Mouse) 17199
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
multicellular organism development
UV protection
positive regulation of protein kinase A signaling
sensory perception of pain
positive regulation of cAMP biosynthetic process
negative regulation of tumor necrosis factor production
intracellular signal transduction
melanin biosynthetic process
pigmentation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein kinase B signaling
UV-damage excision repair
positive regulation of protein kinase C signaling
G-protein coupled receptor signaling pathway
regulation of feeding behavior
positive regulation of feeding behavior
signal transduction
