Invitrogen

MCK10 Polyclonal Antibody

Name: MCK10 Polyclonal Antibody
Brand: Invitrogen
SKU: PA1-30315

查看其他28个MCK10抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (5)

MCK10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 5

MCK10 Antibody (PA1-30315) in IHC (P)

Immunohistochemistry (Paraffin) analysis of MCK10 in human kidney tissue using MCK10 Polyclonal Antibody (Product # PA1-30315).

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Immunogen image

Immunogen Image MCK10 Polyclonal Antibody

产品信息

PA1-30315

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

免疫组化（石蜡） (IHC (P))

1:10-1:50

流式细胞分析 (Flow)

1:25

产品规格

种属反应

Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 17-47 amino acids from the N-terminal region of human DDR1.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_1957217

产品详细信息

Detects a band at approximately 100 kDa (predicted molecular weight of 105 kDa). Positive control of placenta lysate suggested.

靶标信息

DDR1 is a receptor tyrosine kinase activated by collagen and is reported to regulate adhesion, cell migration and other cellular processes. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CD167 antigen-like family member A; CD167a; Cell adhesion kinase; DAAP-278B20.1; DDR1d; discoidin domain receptor family, member 1; Discoidin receptor tyrosine kinase; Epithelial discoidin domain receptor 1; Epithelial discoidin domain-containing receptor 1; HGK2; Mammary carcinoma kinase 10; MCK-10; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase receptor type 4; neurotrophic tyrosine kinase, receptor, type 4; protein-tyrosine kinase 3; Protein-tyrosine kinase 3A; protein-tyrosine kinase PTK-3; Protein-tyrosine kinase RTK-6; PTK3A protein tyrosine kinase 3A; TRK E; Tyrosine kinase DDR; Tyrosine-protein kinase CAK

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基因别名: CAK; CD167; DDR; DDR1; Drd1; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; PTK3D; RTK6; TRKE

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UniProt ID: (Human) Q08345

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Entrez Gene ID: (Human) 780, (Rat) 25678

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功能

transmembrane receptor protein tyrosine kinase activity protein binding collagen binding ATP binding protein tyrosine kinase collagen receptor activity metal ion binding molecular_function transmembrane signal receptor

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