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NeoBiotechnologies
MCM4 (Pan Cancer Marker) Recombinant Rabbit Monoclonal Antibody (MCM4/13209R)
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产品信息
4173-RBM3-P1
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
MCM4/13209R
抗原
Recombinant fragment (around aa 600-800) of human MCM4 protein (exact sequence is proprietary).
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product cellular localization: Nucleus.
Positive control: A-431 cells. Human colon.
Tissue specificity: Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
靶标信息
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDC21 homolog; DNA replication licensing factor MCM4; homolog of S. pombe cell devision cycle 21; minichromosome maintenance deficient 4; P1-CDC21
基因别名: CDC21; CDC54; hCdc21; MCM4; NKCD; NKGCD; P1-CDC21
UniProt ID: (Human) P33991
Entrez Gene ID: (Human) 4173
