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Invitrogen
MCM7 Polyclonal Antibody
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产品信息
PA5-22104
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human MCM7. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.76 mg/mL
规格
76 µg
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (92%), Rat (93%), Zebrafish (85%), Xenopus laevis (88%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDC47 homolog; DNA replication licensing factor MCM7; homolog of S. cerevisiae Cdc47; mini chromosome maintenance deficient 7; minichromosome maintenance deficient 7; minichromosome maintenance protein 7; NB4 apoptosis/differentiation related protein; P1 P85MCM; P1.1-MCM3; protein phosphatase 1, regulatory subunit 104; similar to Homo sapiens mRNA for hMCM2 with GenBank Accession Number D28480.1; unnamed protein product
基因别名: AI747533; CDC47; mCDC47; MCM2; MCM7; Mcmd7; P1.1-MCM3; P1CDC47; P85MCM; PNAS146; PPP1R104
UniProt ID: (Human) P33993, (Mouse) Q61881
Entrez Gene ID: (Human) 4176, (Mouse) 17220, (Rat) 288532
nucleotide binding
DNA binding
DNA helicase activity
single-stranded DNA binding
helicase activity
protein binding
ATP binding
hydrolase activity
ATPase activity
single-stranded DNA-dependent ATP-dependent DNA helicase activity
ATP-dependent DNA helicase activity
DNA-dependent ATPase activity
DNA metabolism protein
double-strand break repair via break-induced replication
DNA replication
DNA replication initiation
DNA strand elongation involved in DNA replication
cellular response to DNA damage stimulus
cell proliferation
response to xenobiotic stimulus
regulation of DNA-dependent DNA replication initiation
regulation of phosphorylation
cellular response to epidermal growth factor stimulus
cellular response to xenobiotic stimulus
DNA unwinding involved in DNA replication
cell cycle
regulation of transcription, DNA-templated
response to drug
cellular response to organic substance
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