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          • Primary Antibodies ›
          • CCL2 (MCP-1) Antibodies

          Invitrogen

          MCP-1 Polyclonal Antibody

          4个已发表图片
          10 篇参考文献
          查看其他60个CCL2 (MCP-1)抗体

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          Cite MCP-1 Polyclonal Antibody

          Additional Information:
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          • 抗体检测数据 (3)
          • 已发表图片 (4)
          MCP-1 Antibody in Immunohistochemistry (IHC)
          Group 53 Created with Sketch.
          MCP-1 Antibody in Immunohistochemistry (IHC)
          Group 53 Created with Sketch.

          图: 1 / 7

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          MCP-1 Antibody (PA5-34505) in IHC

          Immunohistochemistry of CCL2 in human spleen tissue with MCP-1 Polyclonal Antibody (Product # PA5-34505) at 5 µg/mL. {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          查看产品

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          MCP-1 Antibody in Immunohistochemistry (IHC)
          MCP-1 Antibody in Immunohistochemistry (IHC)
          MCP-1 Antibody in Western Blot (WB)
          MCP-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MCP-1 Antibody in Western Blot (WB)
          MCP-1 Antibody in Western Blot (WB)
          MCP-1 Antibody in Western Blot (WB)
          MCP-1 Polyclonal Antibody

          产品信息

          PA5-34505

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1 µg/mL
          查看3篇已发表文章 3篇已发表文章

          免疫组化 (IHC)

          5 µg/mL
          查看5篇已发表文章 5篇已发表文章

          免疫组化(石蜡) (IHC (P))

          -
          查看2篇已发表文章 2篇已发表文章
          产品规格

          种属反应

          Human, Mouse, Rat

          已发表种属

          Human, Mouse, Rat

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          A 17 amino acid peptide near the carboxy terminus of human CCL2
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1 mg/mL

          规格

          100 µg

          纯化类型

          Antigen affinity chromatography

          保存液

          PBS

          内含物

          0.02% sodium azide

          保存条件

          Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2551857

          产品详细信息

          A suggested positive control is rat spleen tissue lysate.

          PA5-34505 can be used with blocking peptide PEP-1548.

          靶标信息

          This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          生物信息学

          蛋白别名: C-C motif chemokine 2; chemokine (C-C motif) ligand 2; chemotactic and activating factor precursor; Genbank Staff Annotation: The small inducible cytokine A2 (SWISS-PROT ACC P13500) is encoded in this mRNA, although it is interrupted and partial, perhaps indicating that this CDS is not the true product of the gamma.1 gene.; H-MCP-1; HC11; immediate-early serum-responsive JE protein; Immediate-early serum-responsive protein JE; MCAF; MCP-1; MGC9434; Monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; Monocyte chemotactic and activating factor; monocyte chemotactic protein; Monocyte chemotactic protein 1; Monocyte secretory protein JE; Mutations: 171:OK; Platelet-derived growth factor-inducible protein JE; RP23-350G1.3; small inducible cytokine A2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible gene JE; Small-inducible cytokine A2; unnamed protein product

          查看更多 收起

          基因别名: AI323594; CCL2; GDCF-2; HC11; HSMCR30; JE; MCAF; MCP-1; MCP1; SCYA2; Sigje; SMC-CF

          查看更多 收起

          UniProt ID: (Human) P13500, (Rat) P14844, (Mouse) P10148

          查看更多 收起

          Entrez Gene ID: (Human) 6347, (Rat) 24770, (Mouse) 20296

          查看更多 收起

          功能
          protein kinase activity receptor binding cytokine activity protein binding chemokine activity CCR2 chemokine receptor binding chemoattractant activity CCR chemokine receptor binding G-protein coupled receptor binding heparin binding cytokine intercellular signal molecule
          参与通路
          angiogenesis monocyte chemotaxis protein phosphorylation chemotaxis inflammatory response immune response humoral immune response cytoskeleton organization cell adhesion signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger JAK-STAT cascade regulation of cell shape response to bacterium organ morphogenesis positive regulation of gene expression positive regulation of macrophage chemotaxis viral genome replication cytokine-mediated signaling pathway sensory perception of pain cellular homeostasis positive regulation of cell migration negative regulation of glial cell apoptotic process helper T cell extravasation chemokine (C-C motif) ligand 2 signaling pathway negative regulation of neuron apoptotic process astrocyte cell migration cellular response to fibroblast growth factor stimulus eosinophil chemotaxis macrophage chemotaxis positive regulation of T cell activation positive chemotaxis positive regulation of synaptic transmission, glutamatergic antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of calcium ion import positive regulation of glutamate receptor signaling pathway negative regulation of vascular endothelial cell proliferation negative regulation of G1/S transition of mitotic cell cycle positive regulation of endothelial cell apoptotic process positive regulation of apoptotic cell clearance negative regulation of natural killer cell chemotaxis MAPK cascade response to hypoxia positive regulation of leukocyte mediated cytotoxicity positive regulation of endothelial cell proliferation leukocyte migration involved in inflammatory response positive regulation of leukocyte migration positive regulation of cellular extravasation cellular calcium ion homeostasis transforming growth factor beta receptor signaling pathway aging glial cell migration response to heat response to wounding response to mechanical stimulus response to gamma radiation regulation of vascular endothelial growth factor production response to activity negative regulation of angiogenesis positive regulation of cell-cell adhesion neutrophil chemotaxis organ regeneration lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide response to progesterone positive regulation of tumor necrosis factor production cellular response to insulin stimulus positive regulation of collagen biosynthetic process response to vitamin B3 cellular response to drug cellular response to macrophage colony-stimulating factor stimulus cellular response to platelet-derived growth factor stimulus chemokinesis response to drug response to amino acid protein kinase B signaling response to ethanol positive regulation of cell adhesion response to antibiotic vascular endothelial growth factor receptor signaling pathway lymphocyte chemotaxis positive regulation of synaptic transmission response to glucocorticoid positive regulation of nitric-oxide synthase biosynthetic process maternal process involved in female pregnancy maternal process involved in parturition cellular response to retinoic acid cellular response to ATP cellular response to interleukin-6 cellular response to lipoprotein particle stimulus cellular response to high density lipoprotein particle stimulus cellular response to organic cyclic compound cellular response to dexamethasone stimulus positive regulation of monocyte chemotaxis positive regulation of immune complex clearance by monocytes and macrophages positive regulation of protein targeting to membrane monocyte homeostasis
          It has to be done as per old AB suggested Products section.

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