Invitrogen

MCP-1 Monoclonal Antibody (2D8)

19个已发表图片
37 篇参考文献
查看其他57个CCL2 (MCP-1)抗体

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说明书
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产品信息

MA5-17040

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
查看8篇已发表文章 8篇已发表文章

免疫组化 (IHC)

-
查看16篇已发表文章 16篇已发表文章

免疫组化（石蜡） (IHC (P))

1:200-1:1,000
查看1篇已发表文章 1篇已发表文章

免疫组化（冰冻） (IHC (F))

-
查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

1:200-1:1,000
查看4篇已发表文章 4篇已发表文章

流式细胞分析 (Flow)

1:200-1:400
查看2篇已发表文章 2篇已发表文章

酶联免疫吸附实验 (ELISA)

1:10,000
查看2篇已发表文章 2篇已发表文章

中和实验 (Neu)

-
查看2篇已发表文章 2篇已发表文章

亲和纯化 (AP)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse, Non-human primate

已发表种属

C. elegans, Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

2D8

抗原

Purified recombinant fragment of human CCL2 expressed in E. Coli.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2538512

产品详细信息

MA5-17040 targets CCL2 in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human, Mouse, and Non-human primate samples.

The MA5-17040 immunogen is purified recombinant fragment of human CCL2 expressed in E. Coli.

MA5-17040 detects CCL2 which has a predicted molecular weight of approximately 11kDa.

靶标信息

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: C-C motif chemokine 2; chemokine (C-C motif) ligand 2; H-MCP-1; HC11; MCAF; MCP-1; MGC9434; Monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; Monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; Monocyte secretory protein JE; Platelet-derived growth factor-inducible protein JE; RP23-350G1.3; small inducible cytokine A2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; Small-inducible cytokine A2

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基因别名: AI323594; CCL2; GDCF-2; HC11; HSMCR30; JE; MCAF; MCP-1; MCP1; SCYA2; Sigje; SMC-CF

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UniProt ID: (Human) P13500, (Mouse) P10148

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Entrez Gene ID: (Human) 6347, (Mouse) 20296

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功能
protein kinase activity receptor binding chemokine activity heparin binding CCR2 chemokine receptor binding G-protein coupled receptor binding cytokine activity protein binding cytokine intercellular signal molecule
参与通路
MAPK cascade angiogenesis response to hypoxia positive regulation of leukocyte mediated cytotoxicity positive regulation of endothelial cell proliferation leukocyte migration involved in inflammatory response monocyte chemotaxis positive regulation of cellular extravasation protein phosphorylation cellular calcium ion homeostasis chemotaxis inflammatory response humoral immune response cytoskeleton organization cell adhesion signal transduction cell surface receptor signaling pathway transforming growth factor beta receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger JAK-STAT cascade aging regulation of cell shape response to heat response to wounding response to mechanical stimulus response to bacterium organ morphogenesis response to gamma radiation regulation of vascular endothelial growth factor production positive regulation of macrophage chemotaxis response to activity negative regulation of angiogenesis viral genome replication cytokine-mediated signaling pathway cellular homeostasis neutrophil chemotaxis organ regeneration lipopolysaccharide-mediated signaling pathway response to progesterone positive regulation of tumor necrosis factor production cellular response to insulin stimulus positive regulation of collagen biosynthetic process response to vitamin B3 negative regulation of glial cell apoptotic process helper T cell extravasation cellular response to drug cellular response to macrophage colony-stimulating factor stimulus cellular response to platelet-derived growth factor stimulus PERK-mediated unfolded protein response response to amino acid protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of GTPase activity astrocyte cell migration cellular response to fibroblast growth factor stimulus response to ethanol response to antibiotic vascular endothelial growth factor receptor signaling pathway macrophage chemotaxis lymphocyte chemotaxis positive regulation of inflammatory response positive regulation of synaptic transmission positive regulation of T cell activation positive regulation of nitric-oxide synthase biosynthetic process maternal process involved in female pregnancy maternal process involved in parturition chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to ATP cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to high density lipoprotein particle stimulus cellular response to organic cyclic compound cellular response to dexamethasone stimulus positive regulation of monocyte chemotaxis positive regulation of immune complex clearance by monocytes and macrophages positive regulation of calcium ion import positive regulation of protein targeting to membrane positive regulation of apoptotic cell clearance negative regulation of natural killer cell chemotaxis positive regulation of leukocyte migration immune response glial cell migration positive regulation of cell-cell adhesion monocyte homeostasis positive regulation of cell adhesion eosinophil chemotaxis
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