Invitrogen

MCPT-1 Monoclonal Antibody (285008)

Name: MCPT-1 Monoclonal Antibody (285008)
Brand: Invitrogen
SKU: MA5-61524

查看其他3个MCPT-1抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

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MCPT-1 Antibody (MA5-61524) in WB

Western Blot analysis of MCPT-1 in mouse small intestine using MCPT-1 monoclonal antibody (Product # MA5-61524).

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Immunogen Image MCPT-1 Monoclonal Antibody (285008)

产品信息

MA5-61524

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-50 µg/mL

产品规格

种属反应

Mouse

宿主/亚型

Rat / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

285008

抗原

Mouse myeloma cell line NS0-derived recombinant mouse Mast Cell Protease-1/Mcpt1, Ile21-Lys246

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.5 mg/mL

纯化类型

Protein A/G

保存液

PBS with trehalose

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_3702136

产品详细信息

Reconstitute at 0.5 mg/mL in sterile PBS.

靶标信息

MCPT-1 is the only chymase expressed by intestinal mucosal mast cells, which are found in the intestinal epithelium. Although it is expressed constitutively and is detectable in the sera of normal mice, parasites in the gut cause systemic levels to increase dramatically within two days and peak at two weeks following infection. It plays an important role in host defense against intestinal parasites, as mice deficient in MCPT-1 display delayed response upon infection. Elevated MCPT-1 levels are also observed during intestinal allergic hypersensitivity reactions. The mechanism of its action is not fully understood, although it is believed to increase intestinal permeability similarly to rMCPT-II, possibly by cleaving the proteins at tight junctions between cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。