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Invitrogen
MDA5 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-20338
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 16 amino acid peptide from near the center of human MDA5.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is Daudi cell lysate.
PA5-20338 can be used with blocking peptide PEP-0458.
靶标信息
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CADM-140 autoantigen; clinically amyopathic dermatomyositis autoantigen 140 kDa; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; helicard; helicase; helicase with 2 CARD domains; interferon induced with helicase C domain protein 1; melanoma differentiation-associated gene 5; melanoma differentiation-associated protein 5; MGC133047; murabutide down-regulated protein; RIG-I-like receptor 2; RNA helicase; RNA helicase-DEAD box protein 116; RNA helicase; MDA-5; RNA-dependent ATPase; unnamed protein product
基因别名: 9130009C22Rik; AGS7; Helicard; Hlcd; IDDM19; IMD95; MDA-5; MDA5; RLR-2; SGMRT1
UniProt ID: (Human) Q9BYX4, (Mouse) Q8R5F7
Entrez Gene ID: (Human) 64135, (Mouse) 71586
DNA binding
RNA binding
RNA helicase activity
double-stranded RNA binding
single-stranded RNA binding
protein binding
ATP binding
zinc ion binding
hydrolase activity
ATPase activity
protein domain specific binding
pattern recognition receptor activity
identical protein binding
ribonucleoprotein complex binding
cytoplasmic pattern recognition receptor signaling pathway
signal transduction
detection of virus
response to virus
protein sumoylation
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
regulation of type III interferon production
MDA-5 signaling pathway
negative regulation of viral genome replication
innate immune response
protein oligomerization
defense response to virus
positive regulation of response to cytokine stimulus
cellular response to exogenous dsRNA
cellular response to virus
antiviral innate immune response
mRNA transcription
type I interferon signaling pathway
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
