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Abnova
MECOM Monoclonal Antibody (6A9)
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产品信息
H00002122-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
6A9
抗原
MECOM (NP_005232, 952 a.a. approximately 1050 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: YKSGLSALDH IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL HSTSHSSSNV WHSMARAAAE SSAIQSISH
靶标信息
The MECOM gene (MDS1 and EVI1 Complex Locus) is located on chromosome 3q26.2 and encodes a protein involved in transcriptional regulation. This gene produces multiple transcript variants encoding different isoforms, including MDS1, EVI1, and PRDM3. The EVI1 protein, one of the main isoforms, is characterized by zinc finger motifs, which facilitate DNA binding, and a SET domain responsible for methyltransferase activity. MECOM plays a crucial role in cell proliferation, differentiation, apoptosis, and hematopoiesis. Aberrations in MECOM, particularly overexpression or rearrangements, are associated with various hematological malignancies, including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The MECOM gene's normal function and pathological alterations make it a significant target for research in cancer biology and therapeutics.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AML1-EVI-1 fusion protein; Ecotropic virus integration site 1 protein homolog; EVI-1; Histone-lysine N-methyltransferase MECOM; MDS1; MDS1 and EVI1 complex locus protein; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; Myelodysplasia syndrome 1 protein; Myelodysplasia syndrome-associated protein 1; oncogene EVI1; PR domain 3; unnamed protein product; zinc finger protein Evi1
基因别名: AML1-EVI-1; EVI1; KMT8E; MDS1; MDS1-EVI1; MECOM; PRDM3; RUSAT2
UniProt ID: (Human) Q03112
Entrez Gene ID: (Human) 2122
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
methyltransferase activity
zinc ion binding
transferase activity
protein homodimerization activity
metal ion binding
histone methyltransferase activity (H3-K9 specific)
histone H3 methyltransferase activity
histone H3K9me2 methyltransferase activity
histone H3K9 monomethyltransferase activity
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
apoptotic process
cell differentiation
negative regulation of transforming growth factor beta receptor signaling pathway
methylation
negative regulation of programmed cell death
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JNK cascade
regulation of cell cycle
heterochromatin organization
hematopoietic stem cell proliferation
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