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MECP2 Monoclonal Antibody (1B11)

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MECP2 Monoclonal Antibody (1B11)

产品信息

H00004204-M03

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1-5 µg/mL
-

免疫组化（石蜡） (IHC (P))

3 µg/mL
-

酶联免疫吸附实验 (ELISA)

0.1 ng/mL
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

1B11

抗原

MECP2 (AAH11612, 81 a.a. approximately 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: PKQRRSIIRD RGPMYDDPTL PEGWTRKLKQ RKSGRSAGKY DVYLINPQGK AFRSKVELIA YFEKVGDTSL DPNDFDFTVT GRGSPSRREQ

靶标信息

MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DKFZp686A24160; MeCp-2 protein; MECP2A; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_1; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_2; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_3; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_5; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_6; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_7; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_8; Methyl-CpG-binding protein 2; Rett Syndrome transcript 1; Rett syndrome; MECP2B; transcript variant; transcriptional repressor; involved in Rett syndrome disease; unnamed protein product

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基因别名: AUTSX3; MECP2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT

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UniProt ID: (Human) P51608

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Entrez Gene ID: (Human) 4204

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功能
nucleic acid binding DNA binding chromatin binding transcription corepressor activity RNA binding mRNA binding protein binding methyl-CpG binding double-stranded methylated DNA binding siRNA binding binding, bridging histone reader activity molecular condensate scaffold activity promoter-specific chromatin binding
参与通路
negative regulation of transcription from RNA polymerase II promoter behavioral fear response response to hypoxia startle response neurological system process involved in regulation of systemic arterial blood pressure regulation of respiratory gaseous exchange by neurological system process inositol metabolic process regulation of transcription from RNA polymerase II promoter glutamine metabolic process cellular biogenic amine metabolic process Notch signaling pathway chemical synaptic transmission synapse assembly brain development respiratory gaseous exchange learning memory long-term memory protein localization glucocorticoid metabolic process cell proliferation associative learning adult locomotory behavior visual learning post-embryonic development gene expression regulation of gene expression negative regulation of gene expression glial cell proliferation dendrite development negative regulation of angiogenesis proprioception sensory perception of pain cerebellum development ventricular system development neuron differentiation neuron projection development heterochromatin assembly cardiolipin metabolic process multicellular organismal response to stress social behavior regulation of gene expression, epigenetic neuron maturation negative regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration hypermethylation of CpG island negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter phosphatidylcholine metabolic process regulation of synaptic plasticity cell development catecholamine secretion neuromuscular process controlling posture neuromuscular process negative regulation of developmental process negative regulation of smooth muscle cell differentiation response to other organism excitatory postsynaptic potential positive regulation of glial cell proliferation long-term synaptic potentiation genetic imprinting positive regulation of microtubule nucleation trans-synaptic signaling by BDNF regulation of multicellular organismal development
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