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Invitrogen
MEDI3185 Recombinant Human Monoclonal Antibody
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产品信息
MA562693
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
MEDI3185 is a monoclonal antibody biosimilar designed to inhibit the stromal cell-derived factor 1 (SDF-1) receptor commonly referred to as CXCR4. This biosimilar targets CXCR4 to disrupt its interaction with the ligand SDF-1 which plays a crucial role in various physiological processes including hematopoiesis angiogenesis and immune surveillance. In pathological scenarios such as cancer high CXCR4 expression is associated with tumor progression metastasis and poor prognosis making MEDI3185 a significant asset in experimental cancer therapy research. Its mechanism involves steric hindrance with CXCR4's ligand-binding domain which is crucial for inhibiting the receptor's pro-metastatic signaling pathways. MEDI3185's IgG1 isotype is produced in XtenCHO cells and is formulated in a phosphate-buffered saline solution for research purposes providing stability and efficacy in laboratory settings focused on understanding and intervening in CXCR4-related pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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