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Abnova
MEF2D Polyclonal Antibody, MaxPab™
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MEF2D Antibody (H00004209-D01P) in WB
Western Blot analysis of MEF2D expression in transfected 293T cell line (H00004209-T01) by MEF2D MaxPab polyclonal antibody.
Lane 1: MEF2D transfected lysate(55.90 KDa).
Lane 2: Non-transfected lysate.
Lane 1: MEF2D transfected lysate(55.90 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00004209-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MEF2D (NP_005911.1, 1 a.a. approximately 521 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH SNKLFQYAST DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGEDSLEQS PLLEDKYRRA SEELDGLFRR YGSTVPAPNF AMPVTVPVSN QSSLQFSNPS GSLVTPSLVT SSLTDPRLLS PQQPALQRNS VSPGLPQRPA SAGAMLGGDL NSANGACPSP VGNGYVSARA SPGLLPVANG NSLNKVIPAK SPPPPTHSTQ LGAPSRKPDL RVITSQAGKG LMHHLTEDHL DLNNAQRLGV SQSTHSLTTP VVSVATPSLL SQGLPFSSMP TAYNTDYQLT SAELSSLPAF SSPGGLSLGN VTAWQQPQQP QQPQQPQPPQ QQPPQPQQPQ PQQPQQPQQP PQQQSHLVPV SLSNLIPGSP LPHVGAALTV TTHPHISIKS EPVSPSRERS PAPPPPAVFP AARPEPGDGL SSPAGGSYET GDRDDGRGDF GPTLGLLRPA PEPEAEGSAV KRMRLDTWTL K
靶标信息
This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp686I1536; MADS box transcription enhancer factor 2, polypeptide D; MEF2D/DAZAP1 fusion; Myocyte-specific enhancer factor 2D
基因别名: MEF2D
UniProt ID: (Human) Q14814
Entrez Gene ID: (Human) 4209
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
activating transcription factor binding
protein homodimerization activity
histone deacetylase binding
protein heterodimerization activity
osteoblast differentiation
endochondral ossification
chondrocyte differentiation
transcription from RNA polymerase II promoter
apoptotic process
nervous system development
adult heart development
muscle organ development
skeletal muscle cell differentiation
positive regulation of transcription from RNA polymerase II promoter
