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Invitrogen
MEFV Polyclonal Antibody
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Product Details
PA5-79662
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human MEFV (5-39aa PSDHLLSTLEELVPYDFEKFKFKLQNTSVQKEHSR).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Spleen Tissue, Rat Lung Tissue, HEPA whole cell.
Target Information
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HGNC:6998; Marenostrin; Mediterranean fever; MEFV innate immuity regulator, pyrin; MEFV, pyrin innate immunity regulator; MGC126560; MGC126586; Pyrin; unnamed protein product
Gene Aliases: FMF; MEF; MEFV; PAAND; pyrin; TRIM20
UniProt ID: (Human) O15553, (Rat) Q9JJ25
Entrez Gene ID: (Human) 4210, (Rat) 58923
pattern recognition receptor signaling pathway
immune system process
inflammatory response
regulation of gene expression
positive regulation of autophagy
regulation of interleukin-1 beta production
negative regulation of interleukin-1 beta production
negative regulation of interleukin-12 production
positive regulation of interleukin-1 beta production
response to interferon-gamma
innate immune response
regulation of inflammatory response
negative regulation of inflammatory response
positive regulation of inflammatory response
response to other organism
pyroptosis
negative regulation of macrophage inflammatory protein 1 alpha production
negative regulation of cytokine production involved in inflammatory response
negative regulation of NLRP3 inflammasome complex assembly
pyroptosome complex assembly
biological_process
response to lipopolysaccharide
response to silicon dioxide
positive regulation of cysteine-type endopeptidase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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