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Invitrogen
MEKK4 Polyclonal Antibody
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FIGURE: 1 / 2
MEKK4 Antibody (PA5-99324) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded MEKK4 in human Stomach tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with MEKK4 polyclonal antibody (Product # PA5-99324) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-99324
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MAP3K4(Accession Q9Y6R4), corresponding to amino acid residues A60-R110.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MAP3K4.
Target Information
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: JNKK1; MAP three kinase 1; MAP2K4; MAPK/ERK kinase kinase 4; MEK kinase 4; mitogen activated protein kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase 4; PRKMK4; SAPK/ERK kinase 1; SERK1; T-associated sex reversal
Gene Aliases: D17Rp17; D17Rp17e; KIAA0213; MAP3K4; MAPKKK4; Mek4b; MEKK 4; MEKK4; mKIAA0213; MTK1; RP17; Rp17a; Tas
UniProt ID: (Mouse) O08648
Entrez Gene ID: (Mouse) 26407
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
MAPK cascade
activation of MAPKK activity
activation of MAPK activity
placenta development
protein phosphorylation
response to UV-C
regulation of gene expression
phosphorylation
male germ-line sex determination
intracellular signal transduction
positive regulation of JUN kinase activity
determination of dorsal identity
chorionic trophoblast cell differentiation
positive regulation of p38MAPK cascade
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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