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Invitrogen
MEP1B Polyclonal Antibody
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MEP1B Antibody (PA5-87627) in WB
Western blot analysis of MEP1B in mouse kidney. Samples were incubated with MEP1B Polyclonal antibody (Product # PA5-87627) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-87627
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 480-652 of human MEP1B (NP_0059162)
偶联物
形式
Liquid
浓度
0.63 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: ISGANDDQLQ WPCPWQQATM TLLDQNPDIR QRMSNQRSIT TDPFMTTDNG NYFWDRPSKV GTVALFSNGT QFRRGGGYGT SAFITHERLK SRDFIKGDDV YILLTVEDIS HLNSTQIQLT PAPSVQDLCS KTTCKNDGVC TVRDGKAECR CQSGEDWWYM GERCEKRGST RDT; Positive Samples: Mouse kidney; Cellular Location: Cell membrane, Single-pass type I membrane protein
靶标信息
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EC 3.4.24.63; Endopeptidase-2; meprin A; Meprin A subunit beta; Meprin B; meprin beta
基因别名: Mep-1b; Mep1b
UniProt ID: (Mouse) Q61847
Entrez Gene ID: (Mouse) 17288
