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Invitrogen
MESP1 Polyclonal Antibody
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MESP1 Antibody (PA5-87675) in WB
Western blot analysis of MESP1 in extracts of various cell lines. Samples were incubated with MESP1 Polyclonal antibody (Product # PA5-87675) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-87675
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 149-268 of human MESP1 (NP_0611401)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.54 mg/mL
规格
54 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: RRCRQRGDAG SPRGCPLCPD DCPAQMQTRT QAEGQGQGRG LGLVSAVRAG ASWGSPPACP GARAAPEPRD PPALFAEAAC PEGQAMEPSP PSPLLPGDVL ALLETWMPLS PLEWLPEEPK; Positive Samples: A-549, HeLa, THP-1, Mouse heart, Rat heart; Cellular Location: Nucleus
靶标信息
Mesp1 (mesoderm posterior 1) is a basic helix-loop-helix-type transcription factor, which along with its related proteins, has an essential role in both segmentation and rostro-caudal patterning of somites in the anterior pre-somitic mesoderm. Mesp1 is expressed in many of the precursors of the cardiovascular system and is known to play a role in the process of cardiac morphogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: mesoderm posterior 1 homolog; Mesoderm posterior protein 1; MGC10676
基因别名: bHLHc5; Mesp1
UniProt ID: (Mouse) P97309
Entrez Gene ID: (Rat) 308766, (Mouse) 17292
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
enhancer binding
transcription regulatory region DNA binding
protein dimerization activity
DNA binding
heart looping
heart morphogenesis
secondary heart field specification
embryonic heart tube morphogenesis
cardiac atrium formation
cardiac ventricle formation
sinus venosus morphogenesis
growth involved in heart morphogenesis
cardioblast anterior-lateral migration
cardioblast migration
transcription from RNA polymerase II promoter
gastrulation
mesodermal cell migration
neurogenesis
signal transduction involved in regulation of gene expression
positive regulation of Notch signaling pathway involved in heart induction
negative regulation of mesodermal cell fate specification
negative regulation of endodermal cell fate specification
endothelial cell differentiation
positive regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
lateral mesoderm development
positive regulation of striated muscle cell differentiation
cardiac muscle cell differentiation
cardiac cell fate determination
sinoatrial node cell differentiation
cardiac vascular smooth muscle cell differentiation
cardioblast migration to the midline involved in heart field formation
positive regulation of hepatocyte differentiation
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
transcription, DNA-templated
regulation of transcription, DNA-templated
Notch signaling pathway
multicellular organism development
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