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Invitrogen
METAP1 Polyclonal Antibody
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产品信息
PA5-44285
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human METAP1 (aa 71-120).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Peptide sequence: GDINTDPWAG YRYTGKLRPH YPLMPTRPVP SYIQRPDYAD HPLGMSESEQ
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 82%
靶标信息
Methionine aminopeptidase 1 (METAP1) is a gene located on chromosome 4q24, encoding an enzyme responsible for the removal of N-terminal methionine residues from newly synthesized proteins. METAP1 is essential for protein maturation and function, as the cleavage of methionine allows subsequent modifications that are crucial for protein stability and activity. This enzyme is ubiquitously expressed in various tissues and plays a significant role in post-translational modification processes, affecting cellular homeostasis and protein regulation. METAP1 is involved in several physiological pathways, including cell cycle progression, signal transduction, and stress response. Dysregulation of METAP1 activity can impact protein function and is associated with diseases like cancer, reflecting its importance in cellular proliferation and growth. Research into METAP1 focuses on its potential as a therapeutic target for modulating protein synthesis and its implications in diseases characterized by uncontrolled cell growth.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp781C0419; EC 3.4.11.18; KIAA0094MAP 1; MAP 1; MAP1; metAP 1; Methionine aminopeptidase 1; Peptidase M; Peptidase M 1
基因别名: KIAA0094; MAP1A; METAP1; MetAP1A
UniProt ID: (Human) P53582
Entrez Gene ID: (Human) 23173
