Product References
Adenosine Methylation Level of miR-125a-5p Promotes Anti-PD-1 Therapy Escape through the Regulation of IGSF11/VSIG3 Expression.
Cancers
Bougras-Cartron G,Nadaradjane A,Joalland MP,Lalier-Bretaudeau L,Raimbourg J,Cartron PF
MA5-27527 was used in Western Blotting to provide a biomarker (m6A-miR-125a-5p level) and two therapeutic solutions (anti-IGSF11 antibody and METTL3 inhibitor) that could potentially address the anti-PD1 therapy failure in the context of precision and personalized medicine.
Wed Jun 14 00:00:00 EDT 2023
The RNA helicase DDX5 promotes viral infection via regulating N6-methyladenosine levels on the DHX58 and NFκB transcripts to dampen antiviral innate immunity.
PLoS pathogens
Xu J,Cai Y,Ma Z,Jiang B,Liu W,Cheng J,Guo N,Wang Z,Sealy JE,Song C,Wang X,Li Y
Published figure using METTL3 monoclonal antibody (Product # MA5-27527) in Western Blot
Thu Apr 01 00:00:00 EDT 2021
The RNA helicase DDX5 promotes viral infection via regulating N6-methyladenosine levels on the DHX58 and NFκB transcripts to dampen antiviral innate immunity.
PLoS pathogens
Xu J,Cai Y,Ma Z,Jiang B,Liu W,Cheng J,Guo N,Wang Z,Sealy JE,Song C,Wang X,Li Y
Published figure using METTL3 monoclonal antibody (Product # MA5-27527) in Western Blot
Thu Apr 01 00:00:00 EDT 2021
The RNA helicase DDX5 promotes viral infection via regulating N6-methyladenosine levels on the DHX58 and NFκB transcripts to dampen antiviral innate immunity.
PLoS pathogens
Xu J,Cai Y,Ma Z,Jiang B,Liu W,Cheng J,Guo N,Wang Z,Sealy JE,Song C,Wang X,Li Y
Published figure using METTL3 monoclonal antibody (Product # MA5-27527) in Western Blot
Thu Apr 01 00:00:00 EDT 2021
A methionine-Mettl3-N6-methyladenosine axis promotes polycystic kidney disease.
Cell metabolism
Ramalingam H,Kashyap S,Cobo-Stark P,Flaten A,Chang CM,Hajarnis S,Hein KZ,Lika J,Warner GM,Espindola-Netto JM,Kumar A,Kanchwala M,Xing C,Chini EN,Patel V
MA5-27527 was used in Western Blotting to show that Mettl3 and m6A levels are increased in mouse and human ADPKD samples and that kidney-specific transgenic Mettl3 expression produces tubular cysts.
Tue Jun 01 00:00:00 EDT 2021