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Bethyl Laboratories
MKI67IP Polyclonal Antibody
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MKI67IP Antibody (A304-047A) in WB
Detection of human MKI67IP by western blot. Samples: Whole cell lysate (50 µg) from HEK293T, HeLa, and Jurkat cells. Antibodies: Affinity purified rabbit anti-MKI67IP antibody (Product # A304-047A) (lot A304-047A-1) used for WB at 0.04 µg/mL. Detection: Chemiluminescence with an exposure time of 10 seconds.
产品信息
A304-047A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 243 to 293 of human MKI67 (FHA domain) Interacting Nucleolar Phosphoprotein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
phosphate/tris citrate, pH 7-8
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
NIFK, also known as nucleolar protein interacting with the forkhead homolog protein, is a gene associated with several cancer types and is considered a potential prognostic biomarker. This gene functions within the nucleolus and plays a critical role in cellular proliferation, metastasis, and invasiveness, particularly noted in hepatocellular carcinoma (HCC) and colorectal cancer. NIFK expression is regulated via several pathways, including the MYC proto-oncogene pathway, and its silencing can lead to decreased fatty acid synthesis in colorectal cancer cells. Furthermore, it's involved in the regulation of innate immunity through pathways such as NF-kB in specific cancer cells. Due to its involvement in cancer progression, NIFK is being explored as a therapeutic target and holds promise for advancing precision medicine strategies across various cancer treatments.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hNIFK; Ki67ip; MKI67 (FHA domain) interacting nucleolar phosphoprotein; MKI67 FHA domain-interacting nucleolar phosphoprotein; Nucleolar phosphoprotein Nopp34; Nucleolar protein interacting with the FHA domain of pKI-67
基因别名: MKI67IP; NIFK; NOPP34
UniProt ID: (Human) Q9BYG3
Entrez Gene ID: (Human) 84365
