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Invitrogen
MKL1 Monoclonal Antibody (CL4281)
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产品信息
MA5-31399
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
CL4281
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: EQEKRAQQPA PAPAPLGTPV KQENSFSSCQ LSQQPLGPAH PFNPSLAAPA TNHIDPCAVA PGPPSVVVKQ EALQPEPEPV PAPQLLLGPQ GPSLIKGVAP PTLITDSTGT HLVLTVTNKN ADSPG
Highest antigen sequence indentity to the following orthologs: Rat - 66%, Mouse - 65%.
靶标信息
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: basic, SAP and coiled-coil domain; Megakaryoblastic leukemia 1 protein; Megakaryocytic acute leukemia protein; mixed lineage leukemia; MKL/myocardin-like protein 1; MRTF-A; Myocardin-related transcription factor A
基因别名: BSAC; KIAA1438; MAL; MKL1; MRTF-A; MRTFA
UniProt ID: (Human) Q969V6
Entrez Gene ID: (Human) 57591
transcription regulatory region sequence-specific DNA binding
RNA polymerase II transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
actin binding
actin monomer binding
protein binding
leucine zipper domain binding
DNA-binding transcription factor
transcription, DNA-templated
positive regulation of transcription via serum response element binding
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of transcription from RNA polymerase II promoter
smooth muscle cell differentiation
negative regulation of apoptotic signaling pathway
