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Invitrogen
MKL2 Monoclonal Antibody (CL1546)
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MKL2 Antibody (MA5-24628) in ICC/IF
Immunofluorescent staining of MKL2 in A549 cells using MKL2 Monoclonal Antibody (CL1546) (Product # MA5-24628) shows specific staining in nuclear speckles and the cytosol in green. Microtubule and nuclear probes are visualized in red and blue, respectively (where available).
产品信息
MA5-24628
产品规格
种属反应
Human
已发表种属
C. elegans
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
CL1546
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: QRPGPMELVE KNILPVDSSV KEAIIGVGKE DYPHTQGDFS FDEDSSDALS PDQPASQESQ GSAASPSEPK VSESPSPVTT NTPAQFASVS PTVPEFLKTP PTADQPPPRP AAPVLPTNTV SSAKPGPALV KQSHPKNP
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 54%.
Binds to an epitope located within the peptide sequence FASVSPTVPEFLKTP as determined by overlapping synthetic peptides.
靶标信息
Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factors A and B (MRTF-A and MRTF-B) interact with SRF and act as stimulators for its transcriptional activity. MRTF-B is crucial for skeletal myogenic differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CTA-276F8.1; Megakaryoblastic leukemia 2; MKL/myocardin like 2; MKL/myocardin-like 2; MKL/myocardin-like protein 2; MRTF-B; Myocardin-related transcription factor B
基因别名: KIAA1243; MKL2; MRTF-B; MRTFB; NPD001
UniProt ID: (Human) Q9ULH7
Entrez Gene ID: (Human) 57496
