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产品信息
MA1-25669
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
G168-15
抗原
Recombinant, full length protein.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
tissue culture supernatant
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
RRID
AB_2145602
产品详细信息
Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Suggested positive controls for this product are tonsil and colon carcinoma.
靶标信息
MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DNA mismatch repair protein Mlh1; MGC5172; MLH-1; mutL homolog 1, colon cancer, nonpolyposis type 2; MutL protein homolog 1
基因别名: COCA2; FCC2; hMLH1; HNPCC; HNPCC2; MLH1
UniProt ID: (Human) P40692
Entrez Gene ID: (Human) 4292
nuclear-transcribed mRNA poly(A) tail shortening
resolution of meiotic recombination intermediates
mismatch repair
double-strand break repair via nonhomologous end joining
male meiosis chromosome segregation
synapsis
spermatogenesis
intrinsic apoptotic signaling pathway in response to DNA damage
female meiosis chromosome segregation
somatic hypermutation of immunoglobulin genes
meiotic metaphase I plate congression
meiotic telomere clustering
isotype switching
negative regulation of mitotic recombination
oogenesis
meiotic spindle midzone assembly
