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Invitrogen
MLK1 Polyclonal Antibody
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Product Details
PA5-33916
Product Specifications
Species Reactivity
Dog,
Horse,
Human,
Mouse,
Non-human primate,
Rabbit
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 18 amino acid peptide from internal region of human MAP3K9.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Panda, Dog, Horse, Rabbit (100%) Hamster, Elephant, Bovine, Bat, Pig (94%).
Target Information
MAP3K9 (MLK1) is a serine/threonine protein kinase that functions in the MAP kinase pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mitogen activated protein kinase kinase kinase 9; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; mixed lineage kinase 1 (tyr and ser/thr specificity)
Gene Aliases: E130314H24Rik; MAP3K9; MEKK9; MLK1; PRKE1
UniProt ID: (Human) P80192, (Mouse) Q3U1V8
Entrez Gene ID: (Dog) 490765, (Horse) 100054289, (Human) 4293, (Rabbit) 100341731, (Mouse) 338372
protein serine/threonine kinase activity
JUN kinase kinase kinase activity
MAP kinase kinase activity
protein binding
ATP binding
protein homodimerization activity
nucleotide binding
protein kinase activity
MAP kinase kinase kinase activity
protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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