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Invitrogen
MLLT11 Polyclonal Antibody
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MLLT11 Antibody (PA5-103027) in IHC (P)
Immunohistochemistry analysis of MLLT11 in human lung cancer and para-carcinoma tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with MLLT11 polyclonal antibody (Product # PA5-103027) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-103027
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MLLT11(Accession Q13015), corresponding to amino acid residues M1-T35.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total MLLT11.
靶标信息
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AF1Q protein; ALL1 fused gene from chromosome 1q; ALL1-fused gene from chromosome 1q; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11; Protein AF1q; zinc finger protein 692
基因别名: AF1Q; AI839562; MLLT11; RGD1305525; Zfp692
UniProt ID: (Human) Q13015, (Rat) Q5M971, (Mouse) P97783
Entrez Gene ID: (Human) 10962, (Rat) 295264, (Mouse) 56772
positive regulation of apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of mitochondrial depolarization
positive regulation of release of cytochrome c from mitochondria
extrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway
biological_process
apoptotic signaling pathway
