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Invitrogen
MMP3 Recombinant Rabbit Monoclonal Antibody (41H63L56)
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MMP3 Antibody (705034) in ICC/IF
Immunofluorescence analysis of MMP3 was performed using MMP3 Recombinant Rabbit Monoclonal Antibody (41H63L56) (Product # 705034) on T98G cells. The cells were fixed with 4% paraformaldehyde for 10 min, permeabilized with 0.1% Triton X-100 for 10 min and blocked with 2% BSA for 1 hr at RT. The cells were stained with primary antibody (1:200) in 0.1% BSA, incubated at 4°C overnight, followed by labelling with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 488 (Product # A-21206, 1:2,000). Panel a) shows ... View More
产品信息
705034
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
41H63L56
抗原
Protein corresponding to human MMP3 [aa101-aa477]
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
Recombinant Rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
靶标信息
MMP3 (stromelysin-1) belongs to the peptidase M10A subfamily. It is secreted in its pro-protein form, and is activated by extracellular proteinase cleavage. MMP3 is capable of binding to zinc and calcium ions, and has metallo-endopeptidase activity. The active enzyme degrades collagen, gelatin, fibronectin, and laminin. It is involved in normal cellular processes such as wound repair and tissue remodeling. Mutations in the gene can result in coronary heart disease 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EC 3.4.24.17; matrix metallo protease; matrix metalloproteinase 3 (stromelysin 1, progelatinase); Matrix metalloproteinase-3; MMP; MMP-3; MMPs; proteoglycanase; SL-1; Stromelysin-1; Stromelysin1; Transin-1; Transin1; unnamed protein product
基因别名: CHDS6; MMP-3; MMP3; SL-1; STMY; STMY1; STR1
UniProt ID: (Human) P08254
Entrez Gene ID: (Human) 4314
immune system process
proteolysis
extracellular matrix disassembly
protein catabolic process
extracellular matrix organization
regulation of cell migration
collagen catabolic process
positive regulation of protein complex assembly
cellular response to reactive oxygen species
innate immune response
negative regulation of protein kinase B signaling
cellular response to lipopolysaccharide
cellular response to amino acid stimulus
cellular response to UV-A
cellular response to nitric oxide
regulation of neuroinflammatory response
response to amyloid-beta
negative regulation of reactive oxygen species metabolic process
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