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7TM Antibodies
MOP, mu-Opioid Receptor Polyclonal Antibody
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FIGURE: 1 / 5
MOP, mu-Opioid Receptor Antibody (7TM0319N) in WB
Validation of the mu -Opioid Receptor in transfected HEK293 cells. Native HEK293 cells (MOCK) or HEK293 cells stably expressing the mu -Opioid Receptor (MOP) were lysed and immunoblotted with the phosphorylation-independent anti-MOP antibody (7TM0319N-WB) at a dilution of 1:1,000.
Product Details
7TM0319N
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide with the sequence LENLEAETAPLP which is present in carboxyl - terminal tail of human, mouse and rat MOP.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The OPRM1 gene encodes the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin and the enkephalins. The OPRM1 receptor is a membrane of the G protein-coupled receptor family. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: G-protein coupled receptor; GPCR; GPCR; MOR-1K1; hMOP; KIAA0403; M-OR-1; MOP; MOP receptor; MOR-1; MOR-1C; MOR1; MOR3; Mu opiate receptor; Mu opioid receptor; mu opioid receptor hMOR-1a; mu opioid receptor splice variant mMOR-1Z; mu opioid receptor splice variant rMOR-1S; mu opioid receptor splice variant rMOR-1Z; Mu-type opioid receptor; MUOR1; Opioid mu receptor; Opioid Receptor; Opioid receptor B; OTTHUMP00000017463; unnamed protein product
Gene Aliases: LMOR; M-OR-1; MOP; MOP-R; MOR; MOR-1; MOR-1O; MOR1; MORA; muOR; OPRM; OPRM1; Oprrm1; Ror-b
UniProt ID: (Human) P35372, (Rat) P33535, (Mouse) P42866
Entrez Gene ID: (Human) 4988, (Rat) 25601, (Mouse) 18390
G-protein alpha-subunit binding
G-protein coupled receptor activity
beta-endorphin receptor activity
opioid receptor activity
voltage-gated calcium channel activity
protein binding
G-protein coupled peptide receptor activity
G-protein beta-subunit binding
morphine receptor activity
neuropeptide binding
protein domain specific binding
filamin binding
signal transducer activity
protein C-terminus binding
G-protein coupled receptor
transmembrane signal receptor
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
sensory perception
negative regulation of cell proliferation
sensory perception of pain
opioid receptor signaling pathway
negative regulation of nitric oxide biosynthetic process
behavioral response to ethanol
positive regulation of neurogenesis
negative regulation of cytosolic calcium ion concentration
negative regulation of Wnt protein secretion
positive regulation of ERK1 and ERK2 cascade
calcium ion transmembrane transport
cellular response to morphine
regulation of cellular response to stress
regulation of N-methyl-D-aspartate selective glutamate receptor activity
acute inflammatory response to antigenic stimulus
immune response
adenylate cyclase-activating dopamine receptor signaling pathway
negative regulation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
locomotory behavior
adenylate cyclase-inhibiting opioid receptor signaling pathway
response to food
positive regulation of appetite
response to lipopolysaccharide
wound healing
response to cocaine
response to morphine
positive regulation of cAMP-mediated signaling
negative regulation of cAMP-mediated signaling
positive regulation of nitric oxide biosynthetic process
response to ethanol
regulation of sensory perception of pain
excitatory postsynaptic potential
response to growth factor
chemical synaptic transmission
negative regulation of cAMP biosynthetic process
cellular response to stress
eating behavior
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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