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Fabgennix
MRP1 Polyclonal Antibody
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Product Details
MRP1-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to unique amino acid sequences on rat multidrug resistance-associated protein 1.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette sub-family C ( CFTR/MRP) member 1a; ATP-binding cassette sub-family C member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1b; DKFZp686N04233; DKFZp781G125; Glutathione-S-conjugate-translocating ATPase ABCC1; leuk; Leukotriene C(4) transporter; LTC4 transporter; multidrug resistance protein 1; Multidrug resistance-associated protein 1; multiple drug resistance-associated protein
Gene Aliases: Abcc1; Abcc1a; Abcc1b; Avcc1a; Mdrap; MRP; Mrp1
UniProt ID: (Rat) Q8CG09, (Mouse) O35379
Entrez Gene ID: (Rat) 24565, (Mouse) 17250
long-chain fatty acid transporter activity
ATP binding
xenobiotic-transporting ATPase activity
drug transmembrane transporter activity
glutathione S-conjugate-exporting ATPase activity
efflux transmembrane transporter activity
oxidoreductase activity
ATPase activity
lipid-transporting ATPase activity
glutathione transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of substances
sphingolipid transporter activity
nucleotide binding
transporter activity
hydrolase activity
ATP-binding cassette (ABC) transporter
drug transmembrane transport
response to oxidative stress
plasma membrane long-chain fatty acid transport
positive regulation of cell migration
phospholipid efflux
glutathione transmembrane transport
response to drug
xenobiotic transport
daunorubicin transport
drug export
transmembrane transport
oxidation-reduction process
cell chemotaxis
negative regulation of neuron death
transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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