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Invitrogen
MSH2 Recombinant Mouse Monoclonal Antibody (10G3-R)
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图: 1 / 8
MSH2 Antibody (MA5-50645) in ICC/IF
Immunocytochemistry analysis of MSH2 in Daudi cells. Cells were fixed in 4% paraformaldehyde for 10 minutes at 37 &(8)451;, permeabilized with 0.05% Triton X-100 in PBS for 20 minutes, and then blocked with 2% negative goat serum for 30 minutes at room temperature. Cells were incubated with MSH2 recombinant monoclonal antibody (Product # MA5-50645) with a dilution of 1:200 in 2% negative goat serum overnight at 4 &(8)451;. Followed by secondary antibody Goat Anti-Mouse IgG H&L (iFluor™ 488) at a dilution of 1:1,000. PBS instead of the prim... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-50645
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
10G3-R
抗原
Synthetic peptide within N-terminal residues of Human MSH2.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive control: RAW264.7 cell lysate, PC-12 cell lysate, A431 cell lysate, NIH-3T3 cell lysate, mouse testis tissue lysate, mouse heart tissue lysate, Daudi, human colon cancer tissue, human appendix tissue, human breast cancer tissue, human stomach cancer tissue, rat brain tissue, mouse large intestine tissue.
Predicted band size: 105 kDa
Subcellular Location: Nucleus, Chromosome.
靶标信息
Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA mismatch repair protein Msh2 transcript; Frameshift mutation results in premature stop; homolog of bacterial MutS proteins [Swiss-Prot accession numbers P23909, P10339, and P27345]; germline mutations are responsible for hereditary nonpolyposis colon cancer (HNPCC); homolog of S. cerevisiae Msh2p [Swiss-Prot accession number P25847] and bacterial MutS proteins [Swiss-Prot accession numbers P23909, P10339, and P27345]; Insertion mutation results in premature stop; mismatch repair protein; Msh2p; mutation causes premature stop; mutS homolog 2, colon cancer, nonpolyposis type 1; mutS protein homolog 2; MutS-like 2; premature stop codon due to mutation; The base insertion results in premature stop; The deletion results in premature stop.; unnamed protein product
基因别名: COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; LYNCH1; MMRCS2; MSH-2
UniProt ID: (Human) P43246, (Mouse) P43247, (Rat) P54275
Entrez Gene ID: (Human) 4436, (Mouse) 17685, (Rat) 81709
magnesium ion binding
four-way junction DNA binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
single-stranded DNA binding
protein binding
ATP binding
enzyme activator activity
DNA-dependent ATPase activity
ATPase activity
centromeric DNA binding
mismatched DNA binding
guanine/thymine mispair binding
dinucleotide insertion or deletion binding
single guanine insertion binding
single thymine insertion binding
dinucleotide repeat insertion binding
oxidized purine DNA binding
MutLalpha complex binding
protein homodimerization activity
ADP binding
ATP-dependent DNA damage sensor activity
in utero embryonic development
somatic recombination of immunoglobulin genes involved in immune response
developmental process involved in reproduction
oxidative phosphorylation
DNA repair
mismatch repair
postreplication repair
double-strand break repair
mitotic recombination
cellular response to DNA damage stimulus
gamete generation
germ cell development
determination of adult lifespan
male gonad development
intrinsic apoptotic signaling pathway in response to DNA damage
response to X-ray
response to UV-B
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
B cell mediated immunity
B cell differentiation
intra-S DNA damage checkpoint
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of neuron apoptotic process
maintenance of DNA repeat elements
isotype switching
negative regulation of DNA recombination
positive regulation of isotype switching to IgA isotypes
positive regulation of isotype switching to IgG isotypes
regulation of cell cycle
spermatogenesis
response to xenobiotic stimulus
response to amino acid
response to quercetin
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