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Invitrogen
MSH2 Recombinant Rabbit Monoclonal Antibody (RM375)
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产品信息
MA5-33073
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
RM375
抗原
Mammalian cell expressed recombinant protein fragment within 500 amino acids of the N-terminus of human MSH2.
偶联物
形式
Liquid
浓度
0.04 mg/mL
规格
4 µg
纯化类型
Protein A
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Specificity: reacts to human DNA mismatch repair protein MSH2.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA mismatch repair protein Msh2; DNA mismatch repair protein Msh2 transcript; Frameshift mutation results in premature stop; hMSH2; homolog of S. cerevisiae Msh2p [Swiss-Prot accession number P25847] and bacterial MutS proteins [Swiss-Prot accession numbers P23909, P10339, and P27345]; Insertion mutation results in premature stop; Msh2p; mutation causes premature stop; mutS homolog 2, colon cancer, nonpolyposis type 1; MutS protein homolog 2; MutS-like 2; premature stop codon due to mutation; The base insertion results in premature stop; The deletion results in premature stop.; unnamed protein product
基因别名: COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; LYNCH1; MMRCS2; MSH-2; MSH2
UniProt ID: (Human) P43246
Entrez Gene ID: (Human) 4436
nucleotide binding
magnesium ion binding
four-way junction DNA binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
single-stranded DNA binding
protein binding
ATP binding
enzyme activator activity
DNA-dependent ATPase activity
ATPase activity
centromeric DNA binding
mismatched DNA binding
guanine/thymine mispair binding
dinucleotide insertion or deletion binding
single guanine insertion binding
single thymine insertion binding
dinucleotide repeat insertion binding
oxidized purine DNA binding
MutLalpha complex binding
protein homodimerization activity
ADP binding
ATP-dependent DNA damage sensor activity
in utero embryonic development
somatic recombination of immunoglobulin genes involved in immune response
oxidative phosphorylation
DNA repair
mismatch repair
postreplication repair
double-strand break repair
mitotic recombination
cellular response to DNA damage stimulus
germ cell development
determination of adult lifespan
male gonad development
intrinsic apoptotic signaling pathway in response to DNA damage
response to X-ray
response to UV-B
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
B cell mediated immunity
B cell differentiation
intra-S DNA damage checkpoint
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of neuron apoptotic process
maintenance of DNA repeat elements
isotype switching
negative regulation of DNA recombination
positive regulation of isotype switching to IgA isotypes
positive regulation of isotype switching to IgG isotypes
regulation of cell cycle
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