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Invitrogen

MSH2 Monoclonal Antibody (SP46)

查看其他46个MSH2抗体

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产品信息

MA5-16379

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化（石蜡） (IHC (P))

1:50
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Monoclonal

类型

Antibody

克隆号

SP46

抗原

Synthetic peptide corresponding to internal region of human MSH2.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Protein A/G

保存液

PBS, pH 7.2, with 1% BSA

内含物

0.1% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2537898

产品详细信息

Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is colon carcinoma.

靶标信息

Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DNA mismatch repair protein Msh2; DNA mismatch repair protein Msh2 transcript; Frameshift mutation results in premature stop; hMSH2; homolog of S. cerevisiae Msh2p [Swiss-Prot accession number P25847] and bacterial MutS proteins [Swiss-Prot accession numbers P23909, P10339, and P27345]; Insertion mutation results in premature stop; Msh2p; mutation causes premature stop; mutS homolog 2, colon cancer, nonpolyposis type 1; MutS protein homolog 2; MutS-like 2; premature stop codon due to mutation; The base insertion results in premature stop; The deletion results in premature stop.; unnamed protein product

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基因别名: COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; LYNCH1; MMRCS2; MSH-2; MSH2

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UniProt ID: (Human) P43246

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Entrez Gene ID: (Human) 4436

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功能
nucleotide binding magnesium ion binding four-way junction DNA binding DNA binding chromatin binding damaged DNA binding double-stranded DNA binding single-stranded DNA binding protein binding ATP binding enzyme activator activity DNA-dependent ATPase activity ATPase activity centromeric DNA binding mismatched DNA binding guanine/thymine mispair binding dinucleotide insertion or deletion binding single guanine insertion binding single thymine insertion binding dinucleotide repeat insertion binding oxidized purine DNA binding MutLalpha complex binding protein homodimerization activity ADP binding ATP-dependent DNA damage sensor activity
参与通路
in utero embryonic development somatic recombination of immunoglobulin genes involved in immune response oxidative phosphorylation DNA repair mismatch repair postreplication repair double-strand break repair mitotic recombination cellular response to DNA damage stimulus germ cell development determination of adult lifespan male gonad development intrinsic apoptotic signaling pathway in response to DNA damage response to X-ray response to UV-B somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments B cell mediated immunity B cell differentiation intra-S DNA damage checkpoint intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of neuron apoptotic process maintenance of DNA repeat elements isotype switching negative regulation of DNA recombination positive regulation of isotype switching to IgA isotypes positive regulation of isotype switching to IgG isotypes regulation of cell cycle
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