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NeoBiotechnologies
MSH6 (DNA Mismatch Repair Protein) Monoclonal Antibody (MSH6, 3085)
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MSH6 (DNA Mismatch Repair Protein) Antibody (2956-MSM5-P1ABX) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of MCF-7 cells using MSH6 (DNA Mismatch Repair Protein) Monoclonal Antibody (Product # 2956-MSM5-P1ABX) followed by goat anti-Mouse IgG conjugated to CF488 (green). Membrane are stained with Phalloidin (Red)..
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
2956-MSM5-P1ABX
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
MSH6, 3085
抗原
Recombinant fragment of human MSH6 protein (around aa 374-540)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is tested in direct ELISA.
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
The DNA mismatch repair MSH2/MSH6 heterodimer is responsible for the detection of DNA damage, and may promote apoptosis in normal cells, thus protecting mammals from ultraviolet-induced malignant transformation and hence the prevention of skin cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G/T mismatch-binding protein; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; mutS protein homolog 6; mutS-alpha 160 kDa subunit; MutS-alpha 160kDa subunit; mutS-like protein 6; Sperm associated protein; sperm-associated protein; unnamed protein product
基因别名: GTBP; GTMBP; HNPCC5; HSAP; LYNCH5; MMRCS3; MSH-6; p160
UniProt ID: (Human) P52701
Entrez Gene ID: (Human) 2956
magnesium ion binding
four-way junction DNA binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
protein binding
ATP binding
DNA-dependent ATPase activity
enzyme binding
mismatched DNA binding
guanine/thymine mispair binding
single guanine insertion binding
single thymine insertion binding
oxidized purine DNA binding
MutLalpha complex binding
protein homodimerization activity
ADP binding
histone H3K36me3 reader activity
ATP-dependent DNA damage sensor activity
meiotic mismatch repair
DNA repair
mismatch repair
chromatin organization
spermatogenesis
determination of adult lifespan
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
maintenance of DNA repeat elements
isotype switching
negative regulation of DNA recombination
intrinsic apoptotic signaling pathway
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